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《化学科学与工程前沿(英文)》 2023年 第17卷 第10期 页码 1503-1515 doi: 10.1007/s11705-022-2294-4
关键词: insoluble drugs polymer inhibition crystallization crystal growth kinetics DFT calculations
null
《医学前沿(英文)》 2014年 第8卷 第4期 页码 445-455 doi: 10.1007/s11684-014-0378-3
Recent evidences suggested that cyclic guanosine monophosphate-specific phosphodiesterase 5 (PDE5) inhibitor represents an important therapeutic target for cardiovascular diseases. Whether and how it ameliorates cardiac fibrosis, a major cause of diastolic dysfunction and heart failure, is unknown. The purpose of this study was to investigate the effects of PDE5 inhibitor on cardiac fibrosis. We assessed cardiac fibrosis and pathology in mice subjected to transverse aortic constriction (TAC). Oral sildenafil, a PDE5 inhibitor, was administered in the therapy group. In control mice, 4 weeks of TAC induced significant cardiac dysfunction, cardiac fibrosis, and cardiac fibroblast activation (proliferation and transformation to myofibroblasts). Sildenafil treatment markedly prevented TAC-induced cardiac dysfunction, cardiac fibrosis and cardiac fibroblast activation but did not block TAC-induced transforming growth factor-β1 (TGF-β1) production and phosphorylation of Smad2/3. In isolated cardiac fibroblasts, sildenafil blocked TGF-β1-induced cardiac fibroblast transformation, proliferation and collagen synthesis. Furthermore, we found that sildenafil induced phosphorylated cAMP response element binding protein (CREB) and reduced CREB-binding protein 1 (CBP1) recruitment to Smad transcriptional complexes. PDE5 inhibition prevents cardiac fibrosis by reducing CBP1 recruitment to Smad transcriptional complexes through CREB activation in cardiac fibroblasts.
关键词: PDE5 cardiac fibrosis TGF-β CREB
Xiaobin Jiang, Linghan Tuo, Dapeng Lu, Baohong Hou, Wei Chen, Gaohong He
《化学科学与工程前沿(英文)》 2017年 第11卷 第4期 页码 647-662 doi: 10.1007/s11705-017-1649-8
关键词: membrane distillation crystallization mathematics model nucleation separation hybrid process
Effects of a structurally related substance on the crystallization of paracetamol
Ali SALEEMI, I.I. ONYEMELUKWE, Zoltan NAGY
《化学科学与工程前沿(英文)》 2013年 第7卷 第1期 页码 79-87 doi: 10.1007/s11705-013-1308-7
关键词: acetaminophen metacetamol crystallization metastable zone width induction time supersaturation control
Interfacial induction and regulation for microscale crystallization process: a critical review
《化学科学与工程前沿(英文)》 2022年 第16卷 第6期 页码 838-853 doi: 10.1007/s11705-021-2129-8
关键词: interfacial crystallization heterogeneous nucleation supersaturation micro/nanostructure process control and intensification
《环境科学与工程前沿(英文)》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1433-3
• Short-term effect of the pyridine exposure on the SAD process was investigated.
关键词: Anammox Inhibition Metabolic pathway Microbial community Pyridine SAD
《农业科学与工程前沿(英文)》 2022年 第9卷 第2期 页码 177-186 doi: 10.15302/J-FASE-2021421
A range of plant species produce root exudates that inhibit ammonia-oxidizing microorganisms. This biological nitrification inhibition (BNI) capacity can decrease N loss and increase N uptake from the rhizosphere. This study sought evidence for the existence and magnitude of BNI capacity in canola ( Brassica napus). Seedlings of three canola cultivars, Brachiaria humidicola(BNI positive) and wheat ( Triticum aestivum) were grown in a hydroponic system. Root exudates were collected and their inhibition of the ammonia oxidizing bacterium, Nitrosospira multiformis, was tested. Subsequent pot experiments were used to test the inhibition of native nitrifying communities in soil. Root exudates from canola significantly reduced nitrification rates of both N. multiformis cultures and native soil microbial communities. The level of nitrification inhibition across the three cultivars was similar to the well-studied high-BNI species B. humidicola. BNI capacity of canola may have implications for the N dynamics in farming systems and the N uptake efficiency of crops in rotational farming systems. By reducing nitrification rates canola crops may decrease N losses, increase plant N uptake and encourage microbial N immobilization and subsequently increase the pool of organic N that is available for mineralization during the following cereal crops.
Inhibition character of crotonaldehyde manufacture wastewater on biological acidification
《环境科学与工程前沿(英文)》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1403-9
• The inhibition of the main organic pollutions in CMW was demonstrated.
关键词: Crotonaldehyde manufacture wastewater Biological acidification Volatile fatty acids Inhibition Toxic units
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《医学前沿(英文)》 2016年 第10卷 第3期 页码 311-319 doi: 10.1007/s11684-016-0460-0
We evaluated the roles of calpain cleavage-related mutations of the integrin β3 cytoplasmic tail in integrin αIIbβ3 bidirectional signaling using a trans-dominant inhibition model. Chimeric Tac-β3 proteins (i.e., Tac-β3, Tac-β3D741, Tac-β3D747, Tac-β3D754, Tac-β3D759, and Tac-β3DNITY) consisting of the extracellular and transmembrane domains of human IL-2 receptor (Tac) and the human integrin β3 cytoplasmic domain were stably expressed in the 123 CHO cells harboring human glycoprotein Ib-IX and wild-type integrin αIIbβ3. The different cells were assayed for stable adhesion and spreading on immobilized fibrinogen, and for binding soluble fibrinogen representing outside-in and inside-out signaling events, respectively. The chimeric protein Tac-β3 inhibited, and Tac-β3DNITY partially attenuated stable adhesion and spreading. Tac-β3, Tac-β3D759, Tac-β3DNITY, and Tac-β3D754, but not Tac-β3D747 or Tac-β3D741, impaired the soluble fibrinogen binding. Results indicated that the bidirectional signaling was significantly inhibited by Tac-β3 and Tac-β3DNITY, albeit to a much lesser extent. Moreover, only inside-out signaling was impaired in the 123/Tac-β3D759 and 123/Tac-β3D754 cells in contrast to an intact bidirectional signaling in the 123/Tac-β3D747 and 123/Tac-β3D741 cells. In conclusion, the calpain cleavage of integrin β3 resulted in the regulatory effects on signaling by interrupting its interaction with cytoplasmic proteins rather than altering its conformation, and may thus regulate platelet function.
关键词: integrin β3 signal transduction trans-dominant inhibition model
The feasibility of coating by cooling crystallization on ibuprofen naked tablets
Fatima Mameri, Ouahiba Koutchoukali, Mohamed Bouhelassa, Anne Hartwig, Leila Nemdili, Joachim Ulrich
《化学科学与工程前沿(英文)》 2017年 第11卷 第2期 页码 211-219 doi: 10.1007/s11705-017-1619-1
关键词: coating solution crystallization ibuprofen tablets sucrose
Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun
《化学科学与工程前沿(英文)》 2018年 第12卷 第2期 页码 283-295 doi: 10.1007/s11705-017-1687-2
关键词: Alzheimer’s disease amyloid β-protein cyclic peptide inhibition protein aggregation
Utilizing melt crystallization fundamentals in the development of a new tabletting technology
Ahmed ABOUZEID,Sandra PETERSEN,Joachim ULRICH
《化学科学与工程前沿(英文)》 2014年 第8卷 第3期 页码 346-352 doi: 10.1007/s11705-014-1443-9
关键词: phase separation melt crystallization tablets process optimization
Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom
Wen Zhang,Jack W. Szostak,Zhen Huang
《化学科学与工程前沿(英文)》 2016年 第10卷 第2期 页码 196-202 doi: 10.1007/s11705-016-1565-3
Preparation and crystallization kinetics of micron-sized Mg(OH)
Xingfu SONG, Kefeng TONG, Shuying SUN, Ze SUN, Jianguo YU
《化学科学与工程前沿(英文)》 2013年 第7卷 第2期 页码 130-138 doi: 10.1007/s11705-013-1332-7
关键词: magnesium hydroxide precipitation micron-sized crystallization kinetics
Applications of the crystallization process in the pharmaceutical industry
Sohrab ROHANI
《化学科学与工程前沿(英文)》 2010年 第4卷 第1期 页码 2-9 doi: 10.1007/s11705-009-0297-z
标题 作者 时间 类型 操作
Theoretical insights into influence of additives on sulfamethoxazole crystal growth kinetics and mechanisms
期刊论文
Chronic inhibition of cyclic guanosine monophosphate-specific phosphodiesterase 5 prevented cardiac fibrosisthrough inhibition of transforming growth factor β-induced Smad signaling
null
期刊论文
Progress in membrane distillation crystallization: Process models, crystallization control and innovative
Xiaobin Jiang, Linghan Tuo, Dapeng Lu, Baohong Hou, Wei Chen, Gaohong He
期刊论文
Effects of a structurally related substance on the crystallization of paracetamol
Ali SALEEMI, I.I. ONYEMELUKWE, Zoltan NAGY
期刊论文
simultaneous anammox and denitrification system with short-term pyridine exposure: Process capability, inhibition
期刊论文
ROOT EXUDATES FROM CANOLA EXHIBIT BIOLOGICAL NITRIFICATION INHIBITION AND ARE EFFECTIVE IN INHIBITING
期刊论文
Roles of integrin β3 cytoplasmic tail in bidirectional signal transduction in a trans-dominant inhibition
null
期刊论文
The feasibility of coating by cooling crystallization on ibuprofen naked tablets
Fatima Mameri, Ouahiba Koutchoukali, Mohamed Bouhelassa, Anne Hartwig, Leila Nemdili, Joachim Ulrich
期刊论文
Head-to-tail cyclization of a heptapeptide eliminates its cytotoxicity and significantly increases its inhibition
Shuai Ma, Huan Zhang, Xiaoyan Dong, Linling Yu, Jie Zheng, Yan Sun
期刊论文
Utilizing melt crystallization fundamentals in the development of a new tabletting technology
Ahmed ABOUZEID,Sandra PETERSEN,Joachim ULRICH
期刊论文
Nucleic acid crystallization and X-ray crystallography facilitated by single selenium atom
Wen Zhang,Jack W. Szostak,Zhen Huang
期刊论文
Preparation and crystallization kinetics of micron-sized Mg(OH)
Xingfu SONG, Kefeng TONG, Shuying SUN, Ze SUN, Jianguo YU
期刊论文